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Arduino, D.M. ; Perocchi, F.

Pharmacological modulation of mitochondrial calcium homeostasis.

J. Physiol. 596, 2717-2733 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mitochondria are pivotal organelles in calcium (Ca2+) handling and signalling, constituting intracellular checkpoints for numerous processes that are vital for cell life. Alterations in mitochondrial Ca2+ homeostasis have been linked to a variety of pathological conditions and are critical in the aetiology of several human diseases. Efforts have been taken to harness mitochondrial Ca2+ transport mechanisms for therapeutic intervention, but pharmacological compounds that direct and selectively modulate mitochondrial Ca2+ homeostasis are currently lacking. New avenues have, however, emerged with the breakthrough discoveries on the genetic identification of the main players involved in mitochondrial Ca2+ influx and efflux pathways and with recent hints towards a deep understanding of the function of these molecular systems. Here, we review the current advances in the understanding of the mechanisms and regulation of mitochondrial Ca2+ homeostasis and its contribution to physiology and human disease. We also introduce and comment on the recent progress towards a systems-level pharmacological targeting of mitochondrial Ca2+ homeostasis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Mitochondria ; Calcium ; Drug Screening ; Calcium Signaling ; Mitochondrial Calcium Uniporter ; Drug Discovery; Rat-liver Mitochondria; Wolf-hirschhorn-syndrome; Local-anesthetic Drugs; Ca2+ Uptake; Ruthenium Red; Essential Component; Heart-mitochondria; Ion Transport; Cell-death; In-vivo
ISSN (print) / ISBN 0928-4257
e-ISSN 1769-7115
Zeitschrift Journal of Physiology - Paris
Quellenangaben Band: 596, Heft: 14, Seiten: 2717-2733 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)