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Friedmann Angeli, J.P.F.* ; Conrad, M.

Selenium and GPX4, a vital symbiosis.

Free Radical Biol. Med. 127, 153-159 (2018)
Postprint DOI PMC
Open Access Green
Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in the form of selenocysteine. Despite this recognized role, much less is known regarding the actual role of selenium in these proteins. Here, we will provide the reader with an overview of the essential role of specific selenoproteins and their link to pathology based on mouse studies and relevant mutations discovered in humans. Additionally, we will cover recent insights linking a non-interchangeable role for selenium in glutathione peroxidase 4 and its function in suppressing ferroptosis. This critical dependency ultimately generates a strong reliance on metabolic pathways that regulate selenium metabolism and its incorporation into proteins, such as the mevalonate pathway.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Cell Death ; Cholesterol Metabolism ; Embryogenesis ; Ferroptosis ; Selenoproteins; Glutathione-peroxidase 4; Transfer-rna Gene; Progressive Cerebellocerebral Atrophy; Mitochondrial Thioredoxin Reductase; Selenoprotein Expression; Targeted Disruption; Selenocysteine Insertion; Cell-death; Mouse; Ferroptosis
ISSN (print) / ISBN 0891-5849
e-ISSN 1873-4596
Zeitschrift Free Radical Biology and Medicine
Quellenangaben Band: 127, Heft: , Seiten: 153-159 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)