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Malik, R.* ; Chauhan, G.* ; Traylor, M.* ; Sargurupremraj, M.* ; Okada, Y.* ; Mishra, A.* ; Rutten-Jacobs, L.* ; Giese, A.K.* ; van der Laan, S.W.* ; Gretarsdottir, S.* ; Anderson, C.D.* ; Chong, M.* ; Adams, H.H.H.* ; Ago, T.* ; Almgren, P.* ; Amouyel, P.* ; Ay, H.* ; Bartz, T.M.* ; Benavente, O.R.* ; Bevan, S.* ; Boncoraglio, G.B.* ; Brown, R.D. Jr.* ; Butterworth, A.S.* ; Carrera, C.* ; Carty, C.L.* ; Chasman, D.I.* ; Chen, W.M.* ; Cole, J.W.* ; Correa, A.* ; Cotlarciuc, I.* ; Cruchaga, C.* ; Danesh, J.* ; de Bakker, P.I.W.* ; DeStefano, A.L.* ; den Hoed, M.* ; Duan, Q.* ; Engelter, S.T.* ; Falcone, G.J.* ; Gottesman, R.F.* ; Grewal, R.P.* ; Gudnason, V.* ; Gustafsson, S.* ; Haessler, J.* ; Harris, T.B.* ; Hassan, A.I.* ; Havulinna, A.S.* ; Heckbert, S.R.* ; Dichgans, M.* ; MEGASTROKE Consortium (Strauch, K.) ; Hsu, F.C.* ; Hyacinth, H.I.* ; Ikram, M.A.* ; Ingelsson, E.* ; Irvin, M.R.* ; Jian, X.* ; Jiménez-Conde, J.* ; Johnson, J.A.* ; Jukema, J.W.* ; Kanai, M.* ; Keene, K.L.* ; Kissela, B.M.* ; Kleindorfer, D.O.* ; Kooperberg, C.* ; Kubo, M.* ; Lange, L.A.* ; Langefeld, C.D.* ; Langenberg, C.* ; Launer, L.J.* ; Lee, J.M.* ; Lemmens, R.* ; MEGASTROKE Consortium (Müller-Nurasyid, M.)

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Nat. Genet. 50, 524-537 (2018)
Postprint Forschungsdaten DOI PMC
Open Access Green
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 50, Heft: 4, Seiten: 524-537 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)