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Bonadonna, R.C.* ; Renard, E.* ; Cheng, A.-L.* ; Fritsche, A. ; Cali, A.* ; Melas-Melt, L.* ; Umpierrez, G.E.*

Switching to insulin glargine 300 U/mL: Is duration of prior basal insulin therapy important?

Diabetes Res. Clin. Pract. 142, 19-25 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Aims: To assess the impact of duration of prior basal insulin therapy on study outcomes in people with type 2 diabetes mellitus receiving insulin glargine 300 U/mL (Gla-300) or insulin glargine 100 U/mL (Gla-100) for 6 months.Methods: A post hoc patient-level meta-analysis of data from the EDITION 1 and 2 studies. Outcomes included: HbA1c, percentage of participants with >= 1 confirmed or severe hypoglycaemic event at night (00: 00-05: 59 h) or any time (24 h), and body weight change. Data were analysed according to duration of prior basal insulin use: >0-<= 2 years, >2-<= 5 years, >5 years.Results: This meta-analysis included 1618 participants. HbA(1c) change from baseline to month 6 was comparable between Gla-300 and Gla-100 groups, regardless of duration of prior basal insulin therapy. The lower risk with Gla-300 versus Gla-100 of >= 1 confirmed (<= 3.9 mmol/L [<= 70 mg/dL]) or severe hypoglycaemic event, at night or any time (24 h), was unaffected by duration of prior basal insulin therapy. Similarly, weight change was unaffected by duration of prior basal insulin therapy.Conclusions: Switching to Gla-300 from other basal insulin therapies provided comparable glycaemic control with lower risk of hypoglycaemia versus Gla-100, regardless of duration of prior basal insulin therapy.Clinical trial registration: NCT01499082, NCT01499095 (ClinicalTrials. gov).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Basal Insulin ; Duration Of Insulin Therapy ; Insulin Glargine ; Type 2 Diabetes Mellitus; American-diabetes-association; Microvascular Complications; Position Statement; Glycemic Control; Glucose Control; 100 Units/ml; Hypoglycemia; People; Predictors; Type-1
ISSN (print) / ISBN 0168-8227
e-ISSN 1872-8227
Zeitschrift Diabetes Research and Clinical Practice
Quellenangaben Band: 142, Heft: , Seiten: 19-25 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)