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Fiedler, L.* ; Kellner, M. ; Oos, R.* ; Böning, G.* ; Ziegler, S.* ; Bartenstein, P.* ; Zeidler, R. ; Gildehaus, F.J.* ; Lindner, S.*

Fully automated production and characterization of 64Cu and proof-of-principle small-animal PET imaging using 64Cu-labelled CA XII targeting 6A10 fab.

ChemMedChem 13, 1230-1237 (2018)
Postprint DOI PMC
Open Access Green
64Cu is a cyclotron-produced radionuclide which offers, due to its characteristic decay scheme the possibility to combine PET investigations with radiotherapy. We evaluated the Alceo sys-tem from Comecer SpA to automatically produce 64Cu for radiolabelling purposes. We established a 64Cu production routine with high yields and radionuclide purity in combination with excellent operator radiation protection. The carbonic anhydrase XII targeting 6A10 antibody fab fragment was successfully radiolabelled with the produced 64Cu and proof of principle small animal PET experiments on mice bearing glioma xenografts were performed. We obtained a high tumor-to-contralateral muscle ratio, which encourages further in vivo investigations of the radioconjugate regarding a possible application in diagnostic tumor imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 64cu ; 6a10 Fab ; Comecer Alceo ; Pet ; Solid Target; Pml Nuclear-bodies; Monoclonal-antibodies; E1b-55k Oncoprotein; Messenger-rna; E3 Ligase; Dependent Degradation; 55-kilodalton Protein; Transformed-cells; Cellular-proteins; E1b55k Proteins
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1860-7179
e-ISSN 1860-7187
Zeitschrift ChemMedChem
Quellenangaben Band: 13, Heft: 12, Seiten: 1230-1237 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 1752 N St Nw, Washington, Dc 20036-2904 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e) G-508100-024
G-501500-007
DOI 10.1002/cmdc.201800130
WOS ID WOS:000435773200008
Scopus ID 85048897969
PubMed ID 29667369
Erfassungsdatum 2018-06-22
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