In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
POF Topic(s)30203 - Molecular Targets and Therapies 30204 - Cell Programming and Repair 90000 - German Center for Diabetes Research 30205 - Bioengineering and Digital Health 30201 - Metabolic Health
Forschungsfeld(er)Enabling and Novel Technologies Genetics and Epidemiology