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Förster, K. ; Sass, S. ; Dietrich, O.* ; Pomschar, A.* ; Nährlich, L.* ; Schulze, A.* ; Flemmer, A.W.* ; Ehrhardt, H.* ; Hübener, C.* ; Eickelberg, O. ; Theis, F.J. ; Ertl-Wagner, B.* ; Hilgendorff, A.

LSC Abstract – Early biomarkers indicating the development of neonatal chronic lung disease defined by clinical and imaging parameters.

Eur. Respir. J. 48, PP104 (2016)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Neonatal chronic lung disease, i.e. BPD determines long-term pulmonary and neurologic development. Early markers are urgently needed for timely diagnosis and personalized treatment. The prospective study determined structural and functional changes in the preterm lung at the time of diagnosis and identified early disease markers by proteome screening in plasma in the first week of life. 40 infants (27.7±2.09wks, 984±332g) were included for advanced MRI measurements (3-Tesla) and complemented by Infant Lung function testing (ILFT) in spontaneously breathing infants. Plasma samples were processed for proteomic screening by SOMAscan™. Key findings were confirmed in an independent study cohort (n=21 infants). Statistical analysis used penalized and Poisson regression analysis; for protein analysis confounder effects were subtracted by lasso regression. Statistical analysis confirmed a high correlation of MRI and lung function variables and identified a pattern characterizing changes in the lungs of preterm infants by T2- and T1-weighed image analysis and lung volume measurements as well as ILFT. Functional enrichment analysis showed overrepresentation of the GO categories 'immune function', 'extracellular matrix', 'cellular proliferation/migration', 'organ development' and 'angiogenesis' in infants with BPD. One protein was identified as a potential biomarker. We identified a structural pattern characterizing BPD by advanced MRI confirmed by ILFT. The identified protein indicated BPD development in the first week of life enabling personalized treatment strategies.

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