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Karlas, A. ; Reber, J. ; Liapis, E. ; Paul-Yuan, K. ; Ntziachristos, V.

Multispectral optoacoustic tomography of brown adipose tissue.

Handb. Exp. Pharmacol., DOI: 10.1007/164_2018_141 (2018)
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Open Access Green
MSOT has revolutionized biomedical imaging because it allows anatomical, functional, and molecular imaging of deep tissues in vivo in an entirely noninvasive, label-free, and real-time manner. This imaging modality works by pulsing light onto tissue, triggering the production of acoustic waves, which can be collected and reconstructed to provide high-resolution images of features as deep as several centimeters below the body surface. Advances in hardware and software continue to bring MSOT closer to clinical translation. Most recently, a clinical handheld MSOT system has been used to image brown fat tissue (BAT) and its metabolic activity by directly resolving the spectral signatures of hemoglobin and lipids. This opens up new possibilities for studying BAT physiology and its role in metabolic disease without the need to inject animals or humans with contrast agents. In this chapter, we overview how MSOT works and how it has been implemented in preclinical and clinical contexts. We focus on our recent work using MSOT to image BAT in resting and activated states both in mice and humans.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Brown adipose tissue Hemoglobin oxygenation Metabolic imaging MSOT Optoacoustics Photoacoustics Spectral unmixing
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0171-2004
Zeitschrift Handbook of Experimental Pharmacology
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
DOI 10.1007/164_2018_141
Erfassungsdatum 2018-07-02
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