146.107.240.13146.107.240.13 PuSH - Publikationsserver des Helmholtz Zentrums München: Multicenter analysis of stereotactic radiotherapy of the resection cavity in patients with brain metastases.

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Combs, S.E. ; Bilger, A.* ; Diehl, C. ; Bretzinger, E.* ; Lorenz, H.* ; Oehlke, O.* ; Specht, H.M. ; Kirstein, A. ; Grosu, A.*

Multicenter analysis of stereotactic radiotherapy of the resection cavity in patients with brain metastases.

Cancer Med. 7, 2319-2327 (2018)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cancer Medicine published by John Wiley & Sons Ltd. Brain metastases show a recurrence rate of about 50% after surgical resection. Adjuvant radiotherapy can prevent progression; however, whole-brain radiotherapy (WBRT) can be associated with significant side effects. Local hypofractionated stereotactic radiotherapy (HFSRT) is a good alternative to provide local control with minimal toxicity. In this multicenter analysis, we evaluated the treatment outcome of local HFSRT after resection brain metastases in 181 patients. Patient's characteristics, treatment data as well as follow-up data were collected and analyzed with special focus on local control, locoregional control and survival. After a median follow-up of 12.6 months (range 0.3–80.2 months), the crude rate for local control was 80.5%; 1- and 2-year local recurrence-free survival rates were 75% and 70% (median not reached). Resection cavity size was a significant predictor for local recurrence (P = 0.033). The median overall survival was 16.0 months. Both graded prognostic assessment score and recursive partitioning analysis were accurate predictors of survival. HFSRT leads to excellent local control and has a high potential to consolidate results after surgery; acute and late toxicity is low. Distant intracerebral metastases occur frequently during follow-up, and therefore, a close patient monitoring needs to be warranted if whole-brain radiotherapy is omitted.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cerebal Metastases ; Local Control ; Neurocognitive Benefit ; Resection Cavity ; Stereotactic Radiotherapy; Pml Nuclear-bodies; Monoclonal-antibodies; E1b-55k Oncoprotein; Messenger-rna; E3 Ligase; Dependent Degradation; 55-kilodalton Protein; Transformed-cells; Cellular-proteins; E1b55k Proteins
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2045-7634
e-ISSN 2045-7634
Zeitschrift Cancer Medicine
Quellenangaben Band: 7, Heft: 6, Seiten: 2319-2327 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken, NJ
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
DOI 10.1002/cam4.1477
WOS ID WOS:000435771000009
Scopus ID 85045880356
PubMed ID 29696815
Erfassungsdatum 2018-07-05
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