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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Predictive models for the natural course of atopic dermatitis in childhood based on serum parameters and clinical attributes.
Exp. Dermatol. 27, E17-E17 (2018)
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Meeting abstract
Schlagwörter
Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN
0906-6705
e-ISSN
1600-0625
Zeitschrift
Experimental Dermatology
Quellenangaben
Band: 27,
Heft: 3,
Seiten: E17-E17
Verlag
Wiley
Verlagsort
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed