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Moschovakis, G.L.* ; Bubke, A.* ; Friedrichsen, M.* ; Ristenpart, J.* ; Back, J.W.* ; Falk, C.S.* ; Kremmer, E. ; Förster, R.*

The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.

Cell. Mol. Immunol. 16, 791-799 (2018)
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The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII). Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers. Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression, respectively. Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Collagen-induced Arthritis; Dendritic Cells; Monoclonal-antibody; Cutting Edge; Expression; Anti-cd3; Disease; Ccl21; Ccl19
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1672-7681
Zeitschrift Cellular & Molecular Immunology
Quellenangaben Band: 16, Heft: 10, Seiten: 791-799 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Macmillan Building, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) CF Monoclonal Antibodies (CF-MAB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501760-001
DOI 10.1038/s41423-018-0056-5
WOS ID WOS:000488287800002
Scopus ID 85049598712
Erfassungsdatum 2018-07-19
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