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Nikolakopoulou, P.* ; Chatzigeorgiou, A.* ; Kourtzelis, I.* ; Toutouna, L.* ; Masjkur, J.* ; Arps-Forker, C.* ; Poser, S.W.* ; Rozman, J. ; Rathkolb, B. ; Aguilar-Pimentel, J.A. ; German Mouse Clinic Consortium* ; Wolf, E.* ; Klingenspor, M.* ; Ollert, M.* ; Schmidt-Weber, C.B. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Tsata, V.* ; Sebastian Monasor, L.* ; Troullinaki, M.* ; Witt, A.* ; Anastasiou, V. ; Chrousos, G.* ; Yi, C.-X.* ; García-Cáceres, C. ; Tschöp, M.H. ; Bornstein, S.R.* ; Androutsellis-Theotokis, A.* ; German Mouse Clinic Consortium (Garrett, L. ; Hölter, S.M. ; Zimprich, A. ; Wurst, W. ; Amarie, O.V. ; Graw, J. ; Neff, F.)

Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Sci. Rep. 8:11335 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes affects the brain. In addition to the direct effects of insulin on the brain, diabetes may also impact the brain through modulation of the inflammatory system. Here we investigate how perturbation of circulating insulin levels affects the expression of Hes3, a transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. Our data show that streptozotocin-induced beta-cell damage, high fat diet, as well as metformin, a common type 2 diabetes medication, regulate Hes3 levels in the brain. This work suggests that Hes3 is a valuable biomarker helping to monitor the state of endogenous neural stem and progenitor cells in the context of diabetes mellitus.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Migration Inhibitory Factor; Growth-factor Expression; Neural Stem-cells; Alzheimers-disease; Cognitive Impairment; Signaling Pathway; Diabetic-patients; Gene-expression; Animal-models; Factor Mif
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 8, Heft: 1, Seiten: , Artikelnummer: 11335 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute for Allergy Research (IAF)
Institute of Pancreatic Islet Research (IPI)
Institute of Diabetes and Obesity (IDO)
Institute of Developmental Genetics (IDG)
POF Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
Allergy
Helmholtz Diabetes Center
PSP-Element(e) G-500692-001
G-500600-001
G-505400-001
G-502600-007
G-502200-001
G-500600-004
G-500500-001
G-500500-002
G-500500-006
DOI 10.1038/s41598-018-29434-2
WOS ID WOS:000439965200028
Scopus ID 85050762000
PubMed ID 30054579
Erfassungsdatum 2018-07-30
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