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Nimble and ready to mingle: Transposon outbursts of early development.
Trends Genet. 34, 806-820 (2018)
Transposable elements are the largest individual constituent of mammalian genomes. These elements are highly diverse, a consequence of the multiplicity of genomic habitats that they inhabit and of the complex evolutionary histories that they have developed therein. Intriguingly, a surge of transposable element transcription occurs during mammalian preimplantation development, contributing to the establishment of totipotency and pluripotency and to the activation of the embryonic genome. However, it remains an open question how such an evolutionarily divergent set can mediate such conserved developmental processes. Here, we review transposable element diversity across mammals and their evolutionary significance. We also discuss the implications that their high evolutionary divergence has for the regulation of preimplantation development across mammals.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Cellular Plasticity ; Evolutionary Genomics ; Genome Architecture ; Pluripotency ; Totipotency ; Transposons; Bat Myotis-lucifugus; Rolling-circle Transposons; Endogenous Retroviruses; Preimplantation Embryos; Placental Mammals; Dna Transposons; Evolutionary Dynamics; Eukaryotic Genomes; Line-1 Activity; Ribosomal-rna
ISSN (print) / ISBN
0168-9479
Zeitschrift
Trends in Genetics
Quellenangaben
Band: 34,
Heft: 10,
Seiten: 806-820
Verlag
Elsevier
Verlagsort
84 Theobalds Rd, London Wc1x 8rr, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epigenetics and Stem Cells (IES)