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Rotter, M. ; Brandmaier, S. ; Covic, M. ; Burek, K.* ; Hertel, J.* ; Troll, M. ; Bader, E. ; Adam, J. ; Prehn, C. ; Rathkolb, B. ; Hrabě de Angelis, M. ; Grabe, H.J.* ; Daniel, H.* ; Kantermann, T.* ; Harth, V.* ; Illig, T.* ; Pallapies, D.* ; Behrens, T.* ; Brüning, T.* ; Adamski, J. ; Lickert, H. ; Rabstein, S.* ; Wang-Sattler, R.

Night shift work affects urine metabolite profiles of nurses with early chronotype.

Metabolites 8:45 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate <0.05) affected in nurses working in night shifts. One metabolite, acylcarnitine C10:2, was consistently identified with all three normalization methods. We further observed 11 and 4 metabolites significantly associated with night shift in early and late chronotype classes, respectively. Increased levels of medium- and long chain acylcarnitines indicate a strong impairment of the fatty acid oxidation. Our results show that night shift work influences acylcarnitines and BCAAs, particularly in nurses in the early chronotype class. Women with intermediate and late chronotypes appear to be less affected by night shift work.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Metabolomics ; Urine Normalization ; Women's' Health ; Night Shift Work ; Chronotypes; Circadian Clock; Amino-acids; Sleep; Acylcarnitines; Questionnaire; Creatinine; Melatonin; Quality; Cancer; Normalization
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Zeitschrift Metabolites
Quellenangaben Band: 8, Heft: 3, Seiten: , Artikelnummer: 45 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Diabetes and Regeneration Research (IDR)
Research Unit Genome Analysis Center (IEG-GAC)
Institute of Experimental Genetics (IEG)
Institute of Stem Cell Research (ISF)