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The emerging role of EpCAM in cancer and stem cell signaling.
Cancer Res. 69, 5627-5629 (2009)
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
colorectal-carcinoma; adhesion molecule; breast-cancer; antigen epcam; ep-cam; cadherins; invasion; marker
ISSN (print) / ISBN
0008-5472
e-ISSN
1538-7445
Zeitschrift
Cancer Research
Quellenangaben
Band: 69,
Heft: 14,
Seiten: 5627-5629
Verlag
American Association for Cancer Research (AACR)
Verlagsort
Philadelphia, Pa.
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Molecular Oncology (AGV-KON)