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A temperature-dependent switch in feeding preference improves Drosophila development and survival in the cold.
Dev. Cell 46, 781-793.e4 (2018)
Verlagsversion
DOI
PMC
How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15 degrees C and that the different lipids present in plants improve survival at low temperatures. We show that Drosophila require dietary unsaturated fatty acids present in plants to adjust membrane fluidity and maintain motor coordination. Feeding on plants extends lifespan and survival for many months at temperatures consistent with overwintering in temperate climates. Thus, physiological alterations caused by a temperature-dependent dietary shift could help Drosophila survive seasonal temperature changes.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Drosophila Melanogaster ; Foraging Behavior ; Homeoviscous Adaption ; Insulin Signaling ; Lifespan ; Lipidomics ; Membrane Fluidity ; Overwintering ; Temperature Acclimation; Fatty-acid-composition; Seasonal-changes; Membrane-lipids; Saccharomyces-cerevisiae; Overwintering Larvae; Thermal Adaptation; Shotgun Lipidomics; Cell-membranes; Na+/k+-atpase; Chill-coma
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Zeitschrift
Developmental Cell
Quellenangaben
Band: 46,
Heft: 6,
Seiten: 781-793.e4
Verlag
Elsevier
Verlagsort
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Pancreatic Beta Cell Research (IPI)