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Peplow, C. ; Assfalg, R. ; Beyerlein, A. ; Hasford, J.* ; Bonifacio, E.* ; Ziegler, A.-G.

Blood draws up to 3% of blood volume in clinical trials are safe in children.

Acta Paediatr. 108, 940-944 (2019)
Postprint DOI PMC
Open Access Green
Aim Recommendations for maximum blood draw in children range from 1 to 5% despite limited evidence. The aim of the study was to assess the safety of blood draws in children aged six months to 12 years targeting volumes of 3% of total blood volume. Methods Children who experienced three-monthly blood draws during participation in one of three investigators initiated clinical trials conducted in our institution were examined. In total, 629 venous blood draws were performed in 141 children. Adverse events and blood counts were assessed. Results Overall, 608 adverse events were reported. None of these included symptoms that reflected concerns on blood draw volumes or frequency. Anaemia and red cell or haemoglobin measurements outside the normal age range were not observed. A reduction in haemoglobin, haematocrit, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and mean corpuscular volume was noted in children participating in one of the three trials analysed. Conclusion Regular blood draws of up to 3% of total blood volume were not associated with signs of anaemia or hypovolaemia in young children. We suggest that the European recommendations be revised for clinical studies in which children are not exposed to treatments that are associated with anaemia risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Blood Collection ; Blood Draw Safety In Children ; Paediatric Research ; Safe Phlebotomy ; Single Blood Draw
ISSN (print) / ISBN 0001-656X
e-ISSN 1651-2227
Zeitschrift Acta Paediatrica
Quellenangaben Band: 108, Heft: 5, Seiten: 940-944 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)