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A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.
Parkinsonism Relat. Disord. 60, 43-45 (2019)
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical 'and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
4.360
1.214
15
17
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Parkinson's Disease ; Intestinal Inflammation ; Short Chain Fatty Acids ; Inflammatory Bowel Disease ; Calprotectin ; Nod2 ; Crohn's Disease; Chain Fatty-acids; Bowel-disease; Microbiota; Vagotomy
Sprache
Veröffentlichungsjahr
2019
Prepublished im Jahr
2018
HGF-Berichtsjahr
2018
ISSN (print) / ISBN
1353-8020
e-ISSN
1873-5126
Zeitschrift
Parkinsonism & Related Disorders
Quellenangaben
Band: 60,
Seiten: 43-45
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Neurogenomics (ING)
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-503200-001
WOS ID
WOS:000466258400008
PubMed ID
30292735
Erfassungsdatum
2018-10-22