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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.
Parkinsonism Relat. Disord. 60, 43-45 (2019)
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical 'and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Parkinson's Disease ; Intestinal Inflammation ; Short Chain Fatty Acids ; Inflammatory Bowel Disease ; Calprotectin ; Nod2 ; Crohn's Disease; Chain Fatty-acids; Bowel-disease; Microbiota; Vagotomy
ISSN (print) / ISBN
1353-8020
e-ISSN
1873-5126
Zeitschrift
Parkinsonism & Related Disorders
Quellenangaben
Band: 60,
Seiten: 43-45
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Neurogenomics (ING)