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Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.
Comm. Biol. 1:170 (2018)
The internal organs embedded in the cavities are lined by an epithelial monolayer termed the mesothelium. The mesothelium is increasingly implicated in driving various internal organ pathologies, as many of the normal embryonic developmental pathways acting in mesothelial cells, such as those regulating epithelial-to-mesenchymal transition, also drive disease progression in adult life. Here, we summarize observations from different animal models and organ systems that collectively point toward a central role of epithelial-to-mesenchymal transition in driving tissue fibrosis, acute scarring, and cancer metastasis. Thus, drugs targeting pathways of mesothelium's transition may have broad therapeutic benefits in patients suffering from these diseases.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Sprache
englisch
Veröffentlichungsjahr
2018
HGF-Berichtsjahr
2018
ISSN (print) / ISBN
2399-3642
e-ISSN
2399-3642
Zeitschrift
Communications Biology
Quellenangaben
Band: 1,
Artikelnummer: 170
Verlag
Springer
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology and Medicine (IRBM)
Institute of Lung Health and Immunity (LHI)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-509400-001
G-554000-001
G-554000-001
PubMed ID
30345394
Erfassungsdatum
2018-10-26