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Rewers, M.* ; Hyöty, H.* ; Lernmark, Å.* ; Hagopian, W.* ; She, J.X.* ; Schatz, D.* ; Ziegler, A.-G. ; Toppari, J.* ; Akolkar, B.* ; Krischer, J.*

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Curr. Diab. Rep. 18:136 (2018)
Postprint DOI PMC
Open Access Green
Purpose of ReviewThe environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.Recent FindingsAs of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome.SummaryTEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed omics studies will provide novel information on the pathogenesis of T1D.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Type 1 Diabetes ; Autoimmunity ; Children; Beta-cell Autoimmunity; Celiac-disease Autoimmunity; Islet Autoimmunity; Birth Cohort; Sociodemographic Factors; Autoantibody Appearance; Respiratory-infections; Incidence Trends; Early-childhood; Genetic Risk
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 18, Heft: 12, Seiten: , Artikelnummer: 136 Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)