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Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.
Curr. Opin. Microbiol. 46, 116-122 (2018)
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Trypanosoma-brucei; Functional-characterization; Receptors Pex5; Compartmentation; Identification; Recognition; Glycolysis; Phosphofructokinase; Hexokinase; Inhibitors
ISSN (print) / ISBN
1369-5274
e-ISSN
1879-0364
Zeitschrift
Current opinion in microbiology
Quellenangaben
Band: 46,
Seiten: 116-122
Verlag
Current Biology Ltd.
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Structural Biology (STB)