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Pagel, P. ; Oesterheld, M. ; Stuempflen, V. ; Frishman, D.

The DIMA web resource-exploring the protein domain network.

Bioinformatics 22, 997-998 (2006)
Verlagsversion Volltext DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length protein chains. In this work we present a comprehensive web resource for exploring the Domain Interaction MAp (DIMA), interactively. The tool aims at integration of multiple data sources and prediction techniques, two of which have been implemented so far: domain phylogenetic profiling and experimentally demonstrated domain contacts from known three-dimensional structures. A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter DATABASE
ISSN (print) / ISBN 1367-4803
e-ISSN 1367-4811
Zeitschrift Bioinformatics
Quellenangaben Band: 22, Heft: 8, Seiten: 997-998 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)