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The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project.
Ann. Med. 42, 587-595 (2010)
Introduction. Although the prevalence of celiac disease (CD) has been extensively investigated in recent years, an accurate estimate of CD frequency in the European population is still lacking. The aims of this study were: 1) to establish accurately the prevalence of CD in a large sample of the European population (Finland, Germany, Italy, and UK), including both children and adults; and 2) to investigate whether the prevalence of CD significantly varies between different areas of the European continent. Materials and methods. Samples were drawn from the four populations. All 29,212 participants were tested for CD by tissue transglutaminase (tTG) antibody test. Positive and border-line findings were further tested for serum endomysial antibodies (EMA). All serological determinations were centrally performed. Small-bowel biopsies were recommended to autoantibody-positive individuals. Previously diagnosed cases were identified. Results. The overall CD prevalence (previously diagnosed plus anti-tTG and EMA positives) was 1.0% (95% CI 0.9-1.1). In subjects aged 30-64 years CD prevalence was 2.4% in Finland (2.0-2.8), 0.3% in Germany (0.1-0.4), and 0.7% in Italy (0.4-1.0). Sixty-eight percent of antibody-positive individuals showed small-bowel mucosal changes typical for CD (Marsh II/III lesion). Conclusions. CD is common in Europe. CD prevalence shows large unexplained differences in adult age across different European countries.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Anti-transglutaminase antibodies, celiac disease, epidemiology, population-based screening, prevalence; TISSUE TRANSGLUTAMINASE ANTIBODIES; PRIMARY-CARE; FOLLOW-UP; AT-RISK; POPULATION; TESTS; TIME; AUTOANTIBODIES; MULTICENTER; MORTALITY
ISSN (print) / ISBN
0785-3890
e-ISSN
1365-2060
Zeitschrift
Annals of Medicine
Quellenangaben
Band: 42,
Heft: 8,
Seiten: 587-595
Verlag
Informa Healthcare
Verlagsort
New York
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)