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Modeliing γ-H2AX foci induction to mimic limitations in the scoring technique.
Radiat. Prot. Dosim. 183, 121-125 (2019)
An approach based on track-structure calculations has been developed to take account of artefacts occurring during γ-H2AX foci detection in 2D images of samples analyzed through immunocytochemistry. The need of this works stems from the observed saturation in foci yields measured after X-ray doses higher than few grays, hindering an unambiguous quantification of DNA damage and of radiation effectiveness. The proposed modelling approach allows to simulate the observer's point of view for foci scoring, mimicking the selection of a slice Δz of the cell nucleus due to the microscope depth of field, and applying a clustering algorithm to group together damages within a resolution parameter r. Calculation results were benchmarked with experimental measurements at an early time-point for mouse breast cancer cells, irradiated with X-ray doses in the range 0-5 Gy. The model is able to reproduce the saturation in experimental data.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
Veröffentlichungsjahr
2019
Prepublished im Jahr
2018
HGF-Berichtsjahr
2018
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 183,
Heft: 1-2,
Seiten: 121-125
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501100-004
Scopus ID
85066294285
PubMed ID
30520984
Erfassungsdatum
2018-12-12