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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The mechanisms shaping the single-cell transcriptional landscape.
Curr. Opin. Genet. Dev. 37, 27-35 (2016)
Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and functional diversity within superficially homogeneous populations, and we discuss how fascinating new studies have afforded novel insight into each mechanism. The studies are chosen in part to include initial reports of novel functional genomics tools where the eventual applications will clearly have profound impact on our understanding the dynamics of cell-to-cell transcriptional variation-from individual cells to whole organisms.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0959-437X
e-ISSN
1879-0380
Zeitschrift
Current Opinion in Genetics & Development
Quellenangaben
Band: 37,
Seiten: 27-35
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Pioneer Campus (HPC)