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    The mechanisms shaping the single-cell transcriptional landscape.
        
        Curr. Opin. Genet. Dev. 37, 27-35 (2016)
    
    
    
				Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and functional diversity within superficially homogeneous populations, and we discuss how fascinating new studies have afforded novel insight into each mechanism. The studies are chosen in part to include initial reports of novel functional genomics tools where the eventual applications will clearly have profound impact on our understanding the dynamics of cell-to-cell transcriptional variation-from individual cells to whole organisms.
			
			
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
     
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2016
    
 
     
    
        HGF-Berichtsjahr
        2016
    
 
    
    
        ISSN (print) / ISBN
        0959-437X
    
 
    
        e-ISSN
        1879-0380
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Current Opinion in Genetics & Development
    
 
		
    
        Quellenangaben
        
	    Band: 37,  
	    
	    Seiten: 27-35 
	    
	    
	
    
 
  
         
        
            Verlag
            Elsevier
        
 
         
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Helmholtz Pioneer Campus (HPC)
    
 
     
     
     
     
     	
    
    
        PubMed ID
        26803530
    
    
        Erfassungsdatum
        2019-01-17