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Ovsepian, S.V.

The dark matter of the brain.

Brain Struct. Funct. 224, 973–983 (2019)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action potentials, i.e., are permanently silent. Herein, I review emerging data suggesting massive redundancy of nerve cells in mammalian nervous system, maintained in inhibited state at high energetic costs. Acquired in the course of evolution, these collections of dormant neurons and circuits evade routine functional undertakings, and hence, keep out of the reach of natural selection. Under penetrating stress and disease, however, they occasionally switch in active state and drive a variety of neuro-psychiatric symptoms and behavioral abnormalities. The increasing evidence for widespread occurrence of silent neurons warrants careful revision of functional models of the brain and entails unforeseen reserves for rehabilitation and plasticity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Silent Neurons ; Brain Evolution ; Fmri ; Synchronous Activity ; Schizophrenia ; Disinhibition ; Neuronal Plasticity; Odor Representations; Pyramidal Cells; Steady-state; Sparse; Inhibition; Neurons; Connectivity; Cortex; Schizophrenia; Construction
Sprache
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1863-2653
e-ISSN 1863-2661
Zeitschrift Brain Structure & Function
Quellenangaben Band: 224, Heft: 3, Seiten: 973–983 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
DOI 10.1007/s00429-019-01835-7
WOS ID WOS:000467032400001
Scopus ID 85060214991
PubMed ID 30659350
Erfassungsdatum 2019-02-28
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