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Ekelund, E.* ; Bradley, M.* ; Weidinger, S. ; Jovanovic, D.L.* ; Johansson, C.* ; Lindgren, C.M.* ; Todorova, A. ; Jakob, T. ; Illig, T. ; von Mutius, E.* ; Braun-Fahrländer, C.* ; Doekes, G.* ; Riedler, J.* ; Schehynius, A.* ; Pershagen, G.* ; Kockum, I.* ; Kere, J.*

Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

Acta Derm.-Venereol. 89, 115-121 (2009)
Verlagsversion DOI PMC
Open Access Gold
Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found between eczema and the seven single nucleotide polymorphisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter atopic dermatitis; eczema; genetic association; G protein-coupled receptor for asthma susceptibility; neuropeptide S receptor 1; protein-coupled receptor; atopy patch test; asthma; dermatitis; susceptibility; polymorphism; haplotypes; linkage; allergy; traits;
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0001-5555
e-ISSN 1651-2057
Zeitschrift Acta Dermato-Venereologica
Quellenangaben Band: 89, Heft: 2, Seiten: 115-121 Artikelnummer: , Supplement: ,
Verlag Acta Dermato-Venereologica
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-003
PubMed ID 19325992
DOI 10.2340/00015555-0549
Scopus ID 63049118466
Erfassungsdatum 2009-07-09
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