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Kleinert, M. ; Bojsen-Møller, K.N.* ; Jørgensen, N.B.* ; Svane, M.S.* ; Martinussen, C.* ; Kiens, B.* ; Wojtaszewski, J.F.P.* ; Madsbad, S.* ; Richter, E.A.* ; Clemmensen, C.*

Effect of bariatric surgery on plasma GDF15 in humans.

Am. J. Physiol. Endocrinol. Metab. 316, E615-E621 (2019)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5-4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bariatric Surgery ; Diabetes ; Gdf15 ; Obesity ; Roux-en-y Gastric Bypass; Macrophage Inhibitory Cytokine-1; Insulin-secretion; Weight-loss; Receptor; Biomarker
ISSN (print) / ISBN 0193-1849
e-ISSN 1522-1555
Zeitschrift American Journal of Physiology - Endocrinology and Metabolism
Quellenangaben Band: 316, Heft: 4, Seiten: E615-E621 Artikelnummer: , Supplement: ,
Verlag American Physiological Society
Verlagsort 9650 Rockville Pike, Bethesda, Md 20814 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)