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Königs, S.K.* ; Pallasch, C.P.* ; Lindner, L.H. ; Schwamb, J.* ; Schulz, A.* ; Brinker, R.* ; Claasen, J.* ; Veldurthy, A.* ; Eibl, H.* ; Hallek, M.* ; Wendtner, C.M.*

Erufosine, a novel alkylphosphocholine, induces apoptosis in CLL through a caspase-dependent pathway.

Leuk. Res. 34, 1064-1069 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The alkylphosphocholine (APC) erufosine is a synthetic phospholipid analogue with antineoplastic activity. APC are known to interact with lipid metabolism and modulate cellular signaling pathways, particularly the phosphorylation of Akt. Here, in primary CLL cells induction of apoptosis was detected with an IC50 of 22muM whereas healthy donor PBMC were less sensitive towards erufosine. Treatment with erufosine caused dose-dependent cleavage of PARP, co-incubation with caspase inhibitor z-VAD almost completely abrogated the cytotoxic effect of erufosine indicating a caspase-dependent mechanism of erufosine. Erufosine was shown to induce apoptosis in primary CLL cells and merits further investigation regarding therapeutic options in CLL.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Erufosine; CLL; Apoptosis; Alkylphospholipid
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Zeitschrift Leukemia Research
Quellenangaben Band: 34, Heft: 8, Seiten: 1064-1069 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Tumor Therapy with Hyperthermia (IMI-KTH)