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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
3D bioprinting of functional islets of Langerhans in an alginate/methylcellulose hydrogel blend.
Adv. Healthc. Mater. 8:e1801631 (2019)
Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood-glucose control that some patients with diabetes type 1 exhibit and has seen many advances over the years. Protection of transplanted islets from the immune system can be accomplished by encapsulation within a hydrogel, the most investigated of which is alginate. In this study, islet encapsulation is combined with 3D extrusion bioprinting, an additive manufacturing method which enables the fabrication of 3D structures with a precise geometry to produce macroporous hydrogel constructs with embedded islets. Using a plottable hydrogel blend consisting of clinically approved ultrapure alginate and methylcellulose (Alg/MC) enables encapsulating pancreatic islets in macroporous 3D hydrogel constructs of defined geometry while retaining their viability, morphology, and functionality. Diffusion of glucose and insulin in the Alg/MC hydrogel is comparable to diffusion in plain alginate; the embedded islets continuously produce insulin and glucagon throughout the observation and still react to glucose stimulation albeit to a lesser degree than control islets.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
3d Bioprinting ; Alginate ; Diabetes ; Insulin ; Macroporous ; Pancreatic Islet; Pancreatic-islets; In-vitro; Rat Islets; Nonimmunosuppressed Patients; Insulin-secretion; Beta-cells; Adult-rat; Alginate; Transplantation; Encapsulation
ISSN (print) / ISBN
2192-2640
e-ISSN
2192-2659
Zeitschrift
Advanced healthcare materials
Quellenangaben
Band: 8,
Heft: 7,
Artikelnummer: e1801631
Verlag
Wiley
Verlagsort
Weinheim
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Pancreatic Beta Cell Research (IPI)