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Roll, W.* ; Markwardt, N.A. ; Masthoff, M.* ; Helfen, A.* ; Claussen, J.* ; Eisenblätter, M.* ; Hasenbach, A.* ; Hermann, S.* ; Karlas, A. ; Wildgruber, M.* ; Ntziachristos, V. ; Schäfers, M.*

Multispectral optoacoustic tomography of benign and malignant thyroid disorders: A pilot study.

J. Nucl. Med. 60, 1461-1466 (2019)

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This study aimed at evaluating hybrid multispectral optoacoustic tomography/ultrasound for imaging of thyroid disorders, including Graves' disease and thyroid nodules. Methods: The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves' disease (n = 6), thyroid lobes with healthy tissue (n = 8), benign thyroid nodules (n = 13), and malignant thyroid nodules (n = 3). Results: In Graves' disease, significantly higher deoxygenated hemoglobin (3.18 +/- 0.52 vs. 2.13 +/- 0.62; P = 0.0055) and total hemoglobin (8.34 +/- 0.88 vs. 6.59 +/- 1.16; P = 0.0084) and significantly lower fat content (0.64 +/- 0.37 vs. 1.69 +/- 1.25; P = 0.0293) were found than in healthy controls. Malignant thyroid nodules showed significantly lower saturation of hemoglobin (55.4% +/- 2.6% vs. 60.8% +/- 7.2%; P = 0.0393) and lower fat content (0.62 +/- 0.19 vs. 1.46 +/- 0.87; P = 0.1295) than benign nodules. Conclusion: This pilot study showed the applicability and the potential of hybrid multispectral optoacoustic tomography/ultrasound to semiquantitatively provide tissue characterization and functional parameters in thyroid disorders for improved noninvasive diagnostics of thyroid diseases.

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