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Nyeng, P.* ; Heilmann, S.* ; Löf-Öhlin, Z.M.* ; Pettersson, N.F.* ; Hermann, F.M.* ; Reynolds, A.B.* ; Semb, H.

P120ctn-mediated organ patterning precedes and determines pancreatic progenitor fate.

Dev. Cell 49, 31-47.e9 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Beta Cell ; Cell Segregation ; Ctnnd1 ; Development ; Differentiation ; Niche ; P120ctn ; Pancreas ; Patterning ; Progenitor; P120 Catenin; E-cadherin; Intercellular-adhesion; Acinar Development; Cell; Organogenesis; Dynamics; Lineage; Tubulogenesis; Expression
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Zeitschrift Developmental Cell
Quellenangaben Band: 49, Heft: 1, Seiten: 31-47.e9 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Transl. Stem Cell Research (ITS)