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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ubiquitin ligases in cancer immunotherapy - balancing antitumor and autoimmunity.
Trends Mol. Med. 25, 428-443 (2019)
Considerable progress has been made in understanding the contribution of E3 ubiquitin ligases to health and disease, including the pathogenesis of immunological disorders. Ubiquitin ligases exert exquisite spatial and temporal control over protein stability and function, and are thus crucial for the regulation of both innate and adaptive immunity. Given that immune responses can be both detrimental (autoimmunity) and beneficial (antitumor immunity), it is vital to understand how ubiquitin ligases maintain immunological homeostasis. Such knowledge could reveal novel mechanisms underlying immune regulation and identify new therapeutic approaches to enhance antitumor immunity and safeguard against autoimmunity.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
E3 Ubiquitin Ligase ; Antitumor Immunity ; Autoimmunity ; Immune Checkpoint; Regulatory T-cells; Nf-kappa-b; Cbl-b; Molecular-mechanisms; Adverse Events; Negative Regulator; Melanoma Patients; Adoptive Therapy; Messenger-rnas; Self-tolerance
ISSN (print) / ISBN
1471-4914
e-ISSN
1471-499X
Zeitschrift
Trends in Molecular Medicine
Quellenangaben
Band: 25,
Heft: 5,
Seiten: 428-443
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)