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Yamano, T.* ; Dobeš, J.* ; Vobořil, M.* ; Steinert, M.* ; Brabec, T.* ; Ziętara, N.* ; Dobešová, M.* ; Ohnmacht, C. ; Laan, M.* ; Peterson, P.* ; Benes, V.* ; Sedláček, R.* ; Hanayama, R.* ; Kolář, M.* ; Klein, L.* ; Filipp, D.*

Aire-expressing ILC3-like cells in the lymph node display potent APC features.

J. Exp. Med. 216, 1027-1037 (2019)
Verlagsversion Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the "promiscuous" expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of "classical" hematopoietic lineage markers, and dependence on ROR gamma t. Aire(+) cells are more frequent among lineage-negative ROR gamma t(+) cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4(+). T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Thymic Epithelial-cells; Regulator Gene Aire; Ror-gamma-t; Protein Expression; B-cells; Selection; Antigen; Rank; Generation; Deficient
ISSN (print) / ISBN 0022-1007
e-ISSN 1540-9538
Zeitschrift Journal of Experimental Medicine
Quellenangaben Band: 216, Heft: 5, Seiten: 1027-1037 Artikelnummer: , Supplement: ,
Verlag Rockefeller University Press
Verlagsort 950 Third Ave, 2nd Flr, New York, Ny 10022 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)