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Maccaferri, M.* ; Harris, N.S.* ; Twardziok, S.O. ; Pasam, R.K.* ; Gundlach, H. ; Spannagl, M. ; Ormanbekova, D.* ; Lux, T. ; Prade, V.M. ; Milner, S.G.* ; Himmelbach, A.* ; Mascher, M.* ; Bagnaresi, P.* ; Faccioli, P.* ; Cozzi, P.* ; Lauria, M.* ; Lazzari, B.* ; Stella, A.* ; Manconi, A.* ; Gnocchi, M.* ; Moscatelli, M.* ; Avni, R.* ; Deek, J.* ; Biyiklioglu, S.* ; Frascaroli, E.* ; Corneti, S.* ; Salvi, S.* ; Sonnante, G.* ; Desiderio, F.* ; Marè, C.* ; Crosatti, C.* ; Mica, E.* ; Özkan, H.* ; Kilian, B.* ; De Vita, P.* ; Marone, D.* ; Joukhadar, R.* ; Mazzucotelli, E.* ; Nigro, D.* ; Gadaleta, A.* ; Chao, S.* ; Faris, J.D.* ; Melo, A.T.O.* ; Pumphrey, M.* ; Pecchioni, N.* ; Milanesi, L.* ; Wiebe, K.* ; Ens, J.* ; MacLachlan, R.P.* ; Clarke, J.M.* ; Sharpe, A.G.* ; Koh, C.S.* ; Liang, K.Y.H.* ; Taylor, G.J.* ; Knox, R.* ; Budak, H.* ; Mastrangelo, A.M.* ; Xu, S.S.* ; Stein, N.* ; Hale, I.* ; Distelfeld, A.* ; Hayden, M.J.* ; Tuberosa, R.* ; Walkowiak, S.* ; Mayer, K.F.X. ; Ceriotti, A.* ; Pozniak, C.J.*

Durum wheat genome highlights past domestication signatures and future improvement targets.

Nat. Genet. 51, 885–895 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The domestication of wild emmer wheat led to the selection of modern durum wheat, grown mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome of durum wheat cultivar Svevo. The assembly enabled genome-wide genetic diversity analyses revealing the changes imposed by thousands of years of empirical selection and breeding. Regions exhibiting strong signatures of genetic divergence associated with domestication and breeding were widespread in the genome with several major diversity losses in the pericentromeric regions. A locus on chromosome 5B carries a gene encoding a metal transporter (TdHMA3-B1) with a non-functional variant causing high accumulation of cadmium in grain. The high-cadmium allele, widespread among durum cultivars but undetected in wild emmer accessions, increased in frequency from domesticated emmer to modern durum wheat. The rapid cloning of TdHMA3-B1 rescues a wild beneficial allele and demonstrates the practical use of the Svevo genome for wheat improvement.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Chromosome Conformation Capture; Cadmium Uptake; Wild Emmer; Tetraploid Wheat; Polyploid Wheat; High-density; Gene; Nucleotide; Resistance; Diversity
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 51, Heft: 5, Seiten: 885–895 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Plant Genome and Systems Biology (PGSB)