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Kutschera, A.* ; Dawid, C.* ; Gisch, N.* ; Schmid, C.* ; Raasch, L.* ; Gerster, T.* ; Schäffer, M.* ; Smakowska-Luzan, E.* ; Belkhadir, Y.* ; Vlot, A.C. ; Chandler, C.E.* ; Schellenberger, R.* ; Schwudke, D.* ; Ernst, R.K.* ; Dorey, S.* ; Hückelhoven, R.* ; Hofmann, T.* ; Ranf, S.*

Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants.

Science 364, 178-181 (2019)
Postprint DOI PMC
Open Access Green
In plants, cell-surface immune receptors sense molecular non-self-signatures. Lipid A of Gram-negative bacterial lipopolysaccharide is considered such a non-self-signature. The receptor kinase LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION (LORE) mediates plant immune responses to Pseudomonas and Xanthomonas but not enterobacterial lipid A or lipopolysaccharide preparations. Here, we demonstrate that synthetic and bacterial lipopolysaccharide-copurified medium-chain 3-hydroxy fatty acid (mc-3-OH-FA) metabolites elicit LORE-dependent immunity. The mc-3-OH-FAs are sensed in a chain length- and hydroxylation-specific manner, with free (R)-3-hydroxydecanoic acid [(R)-3-OH-C10:0] representing the strongest immune elicitor. By contrast, bacterial compounds comprising mc-3-OH-acyl building blocks but devoid of free mc-3-OH-FAs-including lipid A or lipopolysaccharide, rhamnolipids, lipopeptides, and acyl-homoserine-lactones-do not trigger LORE-dependent responses. Hence, plants sense low-complexity bacterial metabolites to trigger immune responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Systemic Acquired-resistance; O-specific Polysaccharide; Lipid-a Component; Pseudomonas-aeruginosa; Molecular-patterns; Somatic Antigens; Lipopolysaccharide; Receptor; Identification; Rhamnolipids
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 364, Heft: 6436, Seiten: 178-181 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biochemical Plant Pathology (BIOP)