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Wang, Y.* ; Zhang, Q.* ; Gao, Z.* ; Xin, S. ; Zhao, Y.* ; Zhang, K.* ; Shi, R.* ; Bao, X.

A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis.

Cancer Cell Int. 19:100 (2019)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized therapy.Methods: With the aim to identify a novel mRNA signature associated with overall survival, we analysed LUAD patients with LNM extracted from The Cancer Genome Atlas (TCGA). LASSO Cox regression was applied to build the prediction model. An external cohort was applied to validate the prediction model.Results: We identified a 4-gene signature that could effectively stratify a high-risk subset of these patients, and time-dependent receiver operating characteristic (tROC) analysis indicated that the signature had a powerful predictive ability. Gene Set Enrichment Analysis (GSEA) showed that the high-risk subset was mainly associated with important cancer-related hallmarks. Moreover, a predictive nomogram was established based on the signature integrated with clinicopathological features. Lastly, the signature was validated by an external cohort from Gene Expression Omnibus (GEO).Conclusion: In summary, we developed a robust mRNA signature as an independent factor to effectively classify LUAD patients with LNM into low- and high-risk groups, which might provide a basis for personalized treatments for these patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Transcriptome ; Lung Adenocarcinoma (luad) ; Lymph Node Metastasis (lnm) ; Mrna Signature ; Weighted Gene Co-expression Network Analysis (wgcna) ; Overall Survival (os); Cancer; Expression; Validation; Prognosis
ISSN (print) / ISBN 1475-2867
e-ISSN 1475-2867
Zeitschrift Cancer cell international
Quellenangaben Band: 19, Heft: 1, Seiten: , Artikelnummer: 100 Supplement: ,
Verlag BioMed Central
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
Institute of Molecular Toxicology and Pharmacology (TOXI)