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Diehl, C. ; Halasz, L.M.* ; Wilkens, J.J.* ; Grosu, A.-L.* ; Combs, S.E.

The role of particle therapy for the treatment of skull base tumors and tumors of the Central Nervous System (CNS).

Top. Magn. Reson. Imaging 28, 49-61 (2019)

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Radiation therapy (RT) is a mainstay in the interdisciplinary treatment of brain tumors of the skull base and brain. Technical innovations during the past 2 decades have allowed for increasingly precise treatment with better sparing of adjacent healthy tissues to prevent treatment-related side effects that influence patients' quality of life. Particle therapy with protons and charged ions offer favorable kinetics with sharp dose deposition in a well-defined depth (Bragg-Peak) and a steep radiation fall-off beyond that maximum. This review highlights the role of particle therapy in the management of primary brain tumors and tumors of the skull base.

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