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Borsos, M. ; Perricone, S.M.* ; Schauer, T.* ; Pontabry, J. ; de Luca, K.L.* ; de Vries, S.S.* ; Ruiz-Morales, E.R. ; Torres-Padilla, M.E. ; Kind, J.*

Genome-lamina interactions are established de novo in the early mouse embryo.

Nature 569, 729-733 (2019)
Postprint DOI PMC
Open Access Green
In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome(1,2). However, the contribution of spatial genome organization to the regulation of developmental programs is unclear(3). Here we generate high-resolution maps of genomic interactions with the nuclear lamina (a filamentous meshwork that lines the inner nuclear membrane) in mouse pre-implantation embryos. We reveal that nuclear organization is not inherited from the maternal germline but is instead established de novo shortly after fertilization. The two parental genomes establish lamina-associated domains (LADs)(4) with different features that converge after the 8-cell stage. We find that the mechanism of LAD establishment is unrelated to DNA replication. Instead, we show that paternal LAD formation in zygotes is prevented by ectopic expression of Kdm5b, which suggests that LAD establishment may be dependent on remodelling of H3K4 methylation. Our data suggest a step-wise assembly model whereby early LAD formation precedes consolidation of topologically associating domains.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gene-expression; Chromatin; Domains; H3k4me3; Heterochromatin; Architecture; Landscape; Dynamics; Maps
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Zeitschrift Nature
Quellenangaben Band: 569, Heft: 7758, Seiten: 729-733 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
DOI 10.1038/s41586-019-1233-0
WOS ID WOS:000470144100046
PubMed ID 31118510
Erfassungsdatum 2019-05-27
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