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Czamara, D.* ; Eraslan, G. ; Page, C.M.* ; Lahti, J.* ; Lahti-Pulkkinen, M.* ; Hämäläinen, E.* ; Kajantie, E.* ; Laivuori, H.* ; Villa, P.M.* ; Reynolds, R.M.* ; Nystad, W.* ; Håberg, S.E.* ; London, S.J.* ; O'Donnell, K.J.* ; Garg, E.* ; Meaney, M.J.* ; Entringer, S.* ; Wadhwa, P.D.* ; Buss, C.* ; Jones, M.J.* ; Lin, D.T.S.* ; MacIsaac, J.L.* ; Kobor, M.S.* ; Koen, N.* ; Zar, H.J.* ; Koenen, K.C.* ; Dalvie, S.* ; Stein, D.J.* ; Kondofersky, I. ; Müller, N.S. ; Theis, F.J. ; Räikkönen, K.* ; Binder, E.B.*

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Nat. Commun. 10:2548 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Childhood Maltreatment; Norwegian Mother; Maternal Smoking; Prenatal Stress; Genome-wide; In-utero; Pregnancy; Risk; Birth; Genotype
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: 2548 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)