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Kirjavainen, P.V.* ; Karvonen, A.M.* ; Adams, R.I.* ; Täubel, M.* ; Roponen, M.* ; Tuoresmäki, P.* ; Loss, G.* ; Jayaprakash, B.* ; Depner, M. ; Ege, M.J.* ; Renz, H.* ; Pfefferle, P.I.* ; Schaub, B.* ; Lauener, R.* ; Hyvärinen, A.* ; Knight, R.* ; Heederik, D.J.J.* ; von Mutius, E. ; Pekkanen, J.*

Farm-like indoor microbiota in non-farm homes protects children from asthma development.

Nat. Med. 25, 1089-1095 (2019)
Postprint DOI PMC
Open Access Green
Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today(1). The asthma-protective effect of farms appears to be associated with rich home dust microbiota(2,3), which could be used to model a health-promoting indoor microbiome. Here we show by modeling differences in house dust microbiota composition between farm and non-farm homes of Finnish birth cohorts(4) that in children who grow up in non-farm homes, asthma risk decreases as the similarity of their home bacterial microbiota composition to that of farm homes increases. The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-associated bacterial taxa. The protective effect was independent of richness and total bacterial load and was associated with reduced proinflammatory cytokine responses against bacterial cell wall components ex vivo. We were able to reproduce these findings in a study among rural German children(2) and showed that children living in German non-farm homes with an indoor microbiota more similar to Finnish farm homes have decreased asthma risk. The indoor dust microbiota composition appears to be a definable, reproducible predictor of asthma risk and a potential modifiable target for asthma prevention.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Early-life; Analytical Performance; Childhood Asthma; Moisture Damage; Bacterial; Exposure; Allergy; Diversity; Endotoxin; Dust
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Zeitschrift Nature medicine
Quellenangaben Band: 25, Heft: 7, Seiten: 1089-1095 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Asthma and Allergy Prevention (IAP)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-503300-001
DOI 10.1038/s41591-019-0469-4
WOS ID WOS:000474430400022
PubMed ID 31209334
Erfassungsdatum 2019-08-06
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