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Caputo, M.* ; Raupach-Rosin, H.* ; Karch, A.* ; Borte, M.* ; Lehmann, I.* ; Liebert, U.G.* ; Standl, M. ; Heinrich, J. ; Mikolajczyk, R.T.*

Vaccinations and infections are associated with unrelated antibody titers: An analysis from the german birth cohort study LISA.

Front. Pediatr. 7:254 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers (p < 0.05), while 11 (95%-CI: 6, 17) spurious associations were expected due to multiple testing. In exploratory multivariable analyses, we observed associations between seven investigated IgG titers and 10 exposures; either administered vaccines [e.g., higher anti-hRSV IgG titer in BCG-vaccinated children (regression-coefficient in standard-deviation-units: 0.38; 95%-CI: 0.12, 0.65)] or infections [e.g., higher anti-measles IgG titer in children with reported chickenpox (0.44; 95%-CI: 0.08, 0.80)]. Our results indicate the existence of associations between immunogenic exposures and unrelated antibody titers. Further studies investigating the underlying immunological mechanisms are required.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Humoral Response ; Vaccinations ; Infectious Diseases ; Non-specific Effects ; Immune Response; Respiratory-syncytial-virus; Calmette-guerin; Bcg Vaccination; Trained Immunity; Infections; Protection; Responses; Vaccines; Rubella; Measles
ISSN (print) / ISBN 2296-2360
e-ISSN 2296-2360
Zeitschrift Frontiers in Pediatrics
Quellenangaben Band: 7, Heft: , Seiten: , Artikelnummer: 254 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)