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Lepko, T. ; Pusch, M. ; Müller, T.* ; Schulte, D.* ; Ehses, J.* ; Kiebler, M.* ; Hasler, J. ; Huttner, H.B.* ; Vandenbroucke, R.E.* ; Vandendriessche, C.* ; Modic, M.* ; Martin-Villalba, A.* ; Zhao, S.* ; LLorens-Bobadilla, E.* ; Schneider, A.* ; Fischer, A.* ; Breunig, C. ; Stricker, S.H. ; Götz, M. ; Ninkovic, J.

Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.

EMBO J. 38:e100481 (2019)
Verlagsversion Preprint Forschungsdaten DOI PMC
Open Access Gold
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adult Neurogenesis ; Mir-204 ; Neural Stem Cells ; Neurogenesis ; Neurogenic Priming; Cerebrospinal-fluid; Neuronal Differentiation; Subventricular Zone; Progenitor Cells; Fate Specification; Embryonic Origin; Neurogenesis; Niche; Migration; Transplantation
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 38, Heft: 17, Seiten: , Artikelnummer: e100481 Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)