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Gouttefangeas, C.* ; Schuhmacher, J.* ; Dimitrov, S.

Adhering to adhesion: Assessing integrin conformation to monitor T cells.

Cancer Immunol. Immunother. 68, 1855-1863 (2019)
Postprint DOI PMC
Open Access Green
Monitoring T cells is of major importance for the development of immunotherapies. Recent sophisticated assays can address particular aspects of the anti-tumor T-cell repertoire or support very large-scale immune screening for biomarker discovery. Robust methods for the routine assessment of the quantity and quality of antigen-specific T cells remain, however, essential. This review discusses selected methods that are commonly used for T-cell monitoring and summarizes the advantages and limitations of these assays. We also present a new functional assay, which specifically detects activated beta(2) integrins within a very short time following CD8(+) T-cell stimulation. Because of its unique and favorable characteristics, this assay could be useful for implementation into our T-cell monitoring toolbox.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter T Cell ; Adhesion ; Function ; Immunomonitoring ; Immunotherapy ; Pivac 2018; Quality-assurance; Assay; Panel; Harmonization; Optimization; Lymphocytes; Enumeration; Guidelines; Receptors; Multimers
ISSN (print) / ISBN 0340-7004
e-ISSN 1432-0851
Zeitschrift Cancer Immunology, Immunotherapy
Quellenangaben Band: 68, Heft: 11, Seiten: 1855-1863 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort 233 Spring St, New York, Ny 10013 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)