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Kieser, A.

Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1).

Signal Transduct. 7, 20-33 (2007)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The latent membrane protein 1 (LMP1) of Epstein-Barr virus is a viral oncogene with the potential to antagonize apoptosis and senescence as well as to promote cellular survival and proliferation. LMP1 acts like a constitutively active receptor recruiting signalling molecules typically employed by the cellular tumour necrosis factor-receptor (TNF-R) and Toll-like/interleukin-1-receptor (TIR) families. LMP1 activates the classical and alternative NF-jB pathways, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), the JAK/STAT and phosphatidylinositol 3-kinase (PI3K) pathways. In this article, interactions of LMP1 with host cell signal transduction pathways and their role in LMP1-induced cell transformation are reviewed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter LMP1; viral oncogene; transformation; NF-jB; JNK; viral signalling
ISSN (print) / ISBN 1615-4053
e-ISSN 1615-4061
Zeitschrift Signal Transduction: Receptors, Mediators and Genes
Quellenangaben Band: 7, Heft: 1, Seiten: 20-33 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)