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El-Agroudy, N.N.* ; Kurzbach, A.* ; Rodionov, R.N.* ; O'Sullivan, J.* ; Roden, M.* ; Birkenfeld, A.L. ; Pesta, D.H.*

Are lifestyle therapies effective for NAFLD treatment?

Trends Endocrinol. Metab. 30, 701-709 (2019)
Verlagsversion Article in press DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training are currently the therapeutic strategies of choice. This review covers the influence of macro-nutrient quality and quantity (i.e., low-carbohydrate and high-protein diets), for successful reduction of intrahepatocellular lipids (IHL). Moreover, we discuss the effectiveness of different modalities of physical exercising with and without weight loss. These lifestyle modifications not only provide strategies to reduce IHL but may also hold a still underestimatec potential to induce improvement and/or even remission of NAFLD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Exercise ; Lifestyle Modification ; Nafld ; Nutrition ; Physical Activity ; Weight Loss; Fatty-liver-disease; Fructose Corn Syrup; Mediterranean Diet; Hepatic Steatosis; Insulin Sensitivity; Physical-activity; Lipid-content; Weight-loss; Exercise; Resistance
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1043-2760
e-ISSN 1879-3061
Zeitschrift Trends in Endocrinology and Metabolism
Quellenangaben Band: 30, Heft: 10, Seiten: 701-709 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-012
DOI 10.1016/j.tem.2019.07.013
WOS ID WOS:000489015300005
Scopus ID 85070557435
Erfassungsdatum 2019-09-19
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