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Kappler, L.* ; Lehmann, R.

Mass-spectrometric multi-omics linked to function - State-of-the-art investigations of mitochondria in systems medicine.

Trends Analyt. Chem. 119:115635 (2019)
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Open Access Hybrid
Creative Commons Lizenzvertrag
Multi-omics applications are essential tools in systems medicine and biology. Alterations in molecular fingerprints are closely related to changes in cellular and subcellular function, but a linkage of functional investigations and omics analyses is quite rare. In mitochondria, lipids, proteins and post-translational modifications thereof are directly linked to function but also to structure. However, the complementary combination of multi-omics analyses and functional investigations in mitochondrial research is challenging. Analytical chemists can implement this strategy in systems medicine projects, thereby providing comprehensive results as a base for correct data interpretation and a deeper understanding of the role of mitochondria in health and disease. In this review we will discuss state-of-the-art approaches of this multistep process focussing on analytical, but also pre-analytical aspects, like mitochondrial purification and sample quality control, as joint key for valid functional multi-omics investigations of mitochondria by complementary lipidomics, proteomics and respiratory analyses. (C) 2019 The Authors. Published by Elsevier B.V.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Multi-omics ; Mitochondria ; Lipidomics ; Proteomics ; Respirometry ; Mass Spectrometry ; Purification ; Systems Medicine; Liquid-chromatography; Shotgun Lipidomics; Metabolomics; Extraction; Biomarkers; Proteomics; Lipids
Sprache
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0165-9936
e-ISSN 1873-3689
Zeitschrift TrAC Trends in Analytical Chemistry
Quellenangaben Band: 119, Heft: , Seiten: , Artikelnummer: 115635 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.1016/j.trac.2019.115635
WOS ID WOS:000492864000018
Scopus ID 85071750596
Erfassungsdatum 2019-10-02
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