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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Immune suppression in renal cell carcinoma.
Semin. Cancer Biol. 17, 330-343 (2007)
The clear evidence that tumor-infiltrating lymphocytes with anti-tumor activity exist in situ raises the question why renal cell carcinomas (RCCs) progress in vivo. A complex array of factors and pathways has been identified that impinges on innate and adaptive effector cells thereby inhibiting their activity against RCCs. The current picture of suppressive mechanisms that contribute to the failure of the immune system to control RCCs is reviewed here. Understanding these complex host-tumor interactions has broad implications for successful application of cytokine therapy and other forms of immunotherapy for RCC.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Renal cell carcinoma; Immune suppression; Tumor escape; Cytokine therapies; Immune therapies
ISSN (print) / ISBN
1044-579X
e-ISSN
1096-3650
Zeitschrift
Seminars in Cancer Biology
Quellenangaben
Band: 17,
Heft: 4,
Seiten: 330-343
Verlag
Saunders
Verlagsort
Philadelphia, Pa.
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Immunology (IMI)