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Uribe-Mariño, A.* ; Castiblanco-Urbina, M.A. ; Falconi-Sobrinho, L.L.* ; dos Anjos-Garcia, T.* ; de Oliveira, R.C.* ; Mendes-Gomes, J.* ; da Silva Soares, R.* ; Matthiesen, M.* ; Almada, R.C.* ; De Oliveira, R.* ; Coimbra, N.C.*

The alpha- and beta-noradrenergic receptors blockade in the dorsal raphe nucleus impairs the panic-like response elaborated by medial hypothalamus neurons.

Brain Res. 1725:146468 (2019)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Dorsal raphe nucleus (DRN) neurons are reciprocally connected to the locus coeruleus (LC) and send neural pathways to the medial hypothalamus (MH). The aim of this work was to investigate whether the blockade of alpha(1)-, alpha(2)- or beta-noradrenergic receptors in the DRN or the inactivation of noradrenergic neurons in the LC modify defensive behaviours organised by MH neurons. For this purpose, Wistar male rats received microinjections of WB4101, RX821002, propranolol (alpha(1)-, alpha(2)- and beta-noradrenergic receptor antagonists, respectively) or physiological saline in the DRN, followed 10 min later by MH GABA(A) receptor blockade. Other groups of animals received DSP-4 (a noradrenergic neurotoxin), physiological saline or only a needle insertion (sham group) into the LC, and 5 days later, bicuculline or physiological saline was administered in the MH. In all these cases, after MH treatment, the frequency and duration of defensive responses were recorded over 15 min. An anterograde neural tract tracer was also deposited in the DRN. DRN neurons send pathways to lateral and dorsomedial hypothalamus. Blockade of alpha(1)- and beta-noradrenergic receptors in the DRN decreased escape reactions elicited by bicuculline microinjections in the MH. In addition, a significant increase in anxiety-like behaviours was observed after the blockade of alpha(2)-noradrenergic receptors in the DRN. LC pretreatment with DSP-4 decreased both anxiety- and panic attack-like behaviours evoked by GABA(A) receptor blockade in the MH. In summary, the present findings suggest that the norepinephrine-mediated system modulates defensive reactions organised by MH neurons at least in part via noradrenergic receptors recruitment on DRN neurons.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Defensive Behaviour ; Dorsal Raphe Nucleus ; Locus Coeruleus ; Medial Hypothalamus ; Noradrenergic Receptors ; Anterograde Neural Tract Tracing; Fear-induced Antinociception; Modulate Defensive Behaviors; Periaqueductal Gray-matter; Locus-coeruleus; Ventromedial Hypothalamus; Dorsomedial Hypothalamus; Serotonergic Neurons; Sympathetic Neurons; Transmitter Release; Superior Colliculus
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0006-8993
e-ISSN 1872-6240
Zeitschrift Brain Research
Quellenangaben Band: 1725, Heft: , Seiten: , Artikelnummer: 146468 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500592-001
G-500500-001
DOI 10.1016/j.brainres.2019.146468
WOS ID WOS:000497248100006
Scopus ID 85072835368
PubMed ID 31541642
Erfassungsdatum 2019-10-14
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