PuSH - Publikationsserver des Helmholtz Zentrums München: 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Grandoch, M.* ; Flögel, U.* ; Virtue, S.* ; Maier, J.K.* ; Jelenik, T.* ; Kohlmorgen, C.* ; Feldmann, K.* ; Ostendorf, Y.* ; Castañeda, T.R.* ; Zhou, Z.* ; Yamaguchi, Y.* ; Nascimento, E.B.M.* ; Sunkari, V.G.* ; Goy, C.* ; Kinzig, M.* ; Sörgel, F.* ; Bollyky, P.L.* ; Schrauwen, P.* ; Al-Hasani, H.* ; Roden, M.* ; Keipert, S. ; Vidal-Puig, A.* ; Jastroch, M. ; Haendeler, J.* ; Fischer, J.W.*

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.

Nat. Metab. 1, 546-559 (2019)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metriken
Zusatzinfos

Therapeutic increase of brown adipose tissue (BAT) thermogenesis is of great interest as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, which is synthesized by HA synthases (Has1/Has2/Has3) from sugar precursors and accumulates in diabetic conditions. Its synthesis can be inhibited by the small molecule 4-methylumbelliferone (4-MU). Here, we show that the inhibition of HA-synthesis by 4-MU or genetic deletion of Has2/Has3 improves BAT`s thermogenic capacity, reduces body weight gain, and improves glucose homeostasis independently from adrenergic stimulation in mice on diabetogenic diet, as shown by a magnetic resonance T2 mapping approach. Inhibition of HA synthesis increases glycolysis, BAT respiration and uncoupling protein 1 expression. In addition, we show that 4-MU increases BAT capacity without inducing chronic stimulation and propose that 4-MU, a clinically approved prescription-free drug, could be repurposed to treat obesity and diabetes.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000